Antimicrobial resistance (AMR), or the ability of a microbe to resist the effects of medication previously used to treat them, is a growing threat to both public health and the warfighter.
Representation of the Burkholderia pan-genome and sub-components. The purple circle represents the number of unique genes found within the genus Burkholderia; the red circle represents the genes shared among B. More
The analyte (red) potentially in a complex matrix such as blood and urine. The paper itself could be used to directly collect samples from the air. (Graphic courtesy of Trevor Glaros, Edgewood Chemical Biological Center)
Amy Shurtleff, Ph.D., works in a biosafety level 4 laboratory at USAMRIID. Shurtleff is part of a team that evaluated the protective efficacy of Merck's EBOV vaccine, V920. (Image courtesy of USAMRIID)
Notional image illustrating how light reflected from butterfly wing scales results in unique data when in the presence of different vapors. Experimental data is shown for dichloropentane (orange), a mustard gas More
A single dose of Cyto-111 provides protection in mice at times refractory to antitoxin treatment. Mice lethally intoxicated with 2x LD50 BoNT/A become symptomatic between 6-8 hours after intoxication. Treatment More
Loading TECAN: Researchers remove a sample plate from the robotic handler. With 384 sample spots (including several for calibration/calibration check), a vast number of permutations and combinations of glycosyl More
The Climate SOM Process within SAHARA, including mapping and training phases. The training phase includes interim steps which feedback to themselves iteratively; the iteration count is a tuning parameter. The m More
Image courtesy of U.S. Army RDECOM
Members of the 20th Chemical, Biological, Radiological, Nuclear, Explosives (CBRNE) Command joined senior military leaders, representatives from some of the closest U.S. allies, members of the Threat Reduction More
A number of DNA vaccine delivery devices are in commercial development which have the potential to overcome these logistical burdens. Several of them will be evaluated by medical personnel at the Delivery of Nu More
When Ebola virus disease (EVD) reared its head in May in the Congo, the world was armed with the rVSV-ZEBOV vaccine thanks to interagency collaboration efforts by the Defense Threat Reduction Agency’s Chemical More
Porton Man is a sensor-equipped mannequin capable of detecting and evaluating the impact of chemical and biological agents on warfighter uniforms, gloves and other outerwear. (Photo courtesy of Terrence D’Onofrio, Ph.D.)
Collaboration between Defense Threat Reduction Agency, Chemical and Biological Technologies Department and Wake Forest Institute for Regenerative Medicine resulted in developing organ-on-a-chip technology. The More
Members from the Defense Threat Reduction Agency (DTRA) and the National Nuclear Center (NNC) walk from tunnel closure areas on Degelen Mountain at the Semipalatinsk Test Site in eastern Kazakhstan. The mountai More
The Defense Threat Reduction Agency’s first program manager for the Degelen Mountain infrastructure elimination project in Kazakhstan, Luke Kluchko, walks through scavenged ruins outside the mountain where his More
Members of the Virginia Army National Guard's 34th Civil Support Team provide feedback to members of the Tactical All-Hazards Ensemble program team. (Official DTRA photo)
A U.S. Army soldier wears the DTRA-funded CBLITE uniform during an October 2016 demonstration. Official DTRA Photo.
Continuous electrical sensing during bacterial culture. (Image courtesy of GE Global Research)
Empowering the Development of Genomics Expertise (EDGE) offers a suite of analytical tools to assist with mission and threat analysis of biological threats for operational utility. (Graphics by DTRA)
Continuous Liquid Interface Production (CLIP) Process. Microneedle patches of virtually any design are produced within two to 10 minutes. (Image courtesy of Shaomin Tian, Ph.D., and Sue Mecham, Ph.D.)
Sample to Sequence
Official DTRA graphics
Marburg virus particles (in blue) and sperm originating from the seminiferous tubule, a site of immune privilege and sperm production in the testes, of a non-human primate that survived Marburg virus infection. More
Tony Buhr, Ph.D., a biologist at NSWCDD, works at a biological safety cabinet on DTRA-funded work on biological warfare agents.
Members of the Defense Threat Reduction Agency and the National Nuclear Center in Kazakhstan, stand in front of Degelen Mountain at the Semipalatinsk Test Site where 181 underground test tunnels were destroyed More
A drone flies between the remaining Experimental Field “geese” structures which held instrumentation and diagnostic equipment during the Soviet Union’s first nuclear tests at the Semipalatinsk Test Site in Kazakhstan.
Schematic of platelet membrane-coated nanoparticles (PNPs) for the treatment of immune thrombocytopenia purpura (ITP). (A) To fabricate PNPs, the plasma membrane from fresh platelets is derived and then coated More
Schematic representation of a CNT membrane functionalized with chemical-threat-responsive polymers. In a safe environment the responsive polymer chains are extended and the material allows rapid transport of wa More
Comparison of protection levels provided by two different garments. Garment (1) front and back performance map. Garment (2) front and back performance map.(Courtesy image from Dstl)
Courtesy photo
Members from the Defense Threat Reduction Agency (DTRA) walk from two tunnel closure areas on Degelen Mountain at the Semipalatinsk Test Site in eastern Kazakhstan. The mountain was used by the Soviet Union for More
Defense Threat Reduction Agency's Mark Gibson and Mark Sullivan, program managers for nonproliferation efforts at Semipalatinsk Test Site in Kazakhstan, stands atop Degelen Mountain at a security point overlook More
The auto-inductive cascade for the detection of nerve agent surrogate, DFP, through fluoride (signal) amplification. Figure courtesy of Chemistry - A European Journal
General Director of the National Nuclear Center in the Republic of Kazakhstan Erlan Gadletovich Batyrbekov does an interview with Defense Threat Reduction Agency Public Affairs Team.
Members of the Defense Threat Reduction Agency and the National Nuclear Center in Kazakhstan, stand on top of Degelen Mountain at the Semipalatinsk Test Site in Kazakhstan where 181 underground test tunnels wer More
The Defense Threat Reduction Agency’s first program manager for the Degelen Mountain infrastructure elimination project Luke Kluchko, left, talks with current program manager for the Semipalatinsk Test Site, Ma More
A look at a bore hole dug for underground testing at Semipalatinsk Test Site in Kazakhstan.
Members of the Defense Threat Reduction Agency stand on the fields at Semipaltinsk Test Site in Kazakhstan where experimental equipment and infrastructure was left behind in 1991 after nuclear testing was condu More
Grounds eye view of the remaining Experimental Field “geese” structures which held instrumentation and diagnostic equipment during the Soviet Union’s first nuclear tests at the Semipalatinsk Test Site in Kazakhstan.