Researchers work with wheat samples that are part of ground testing for the first International Space Station plant experiment, scheduled to fly in October 2001. From left are research scientist Oscar Monje and research technicians Lisa Ruffa and Ignacio Eraso. The payload process testing they are performing is one of many studies at the Biological Sciences Branch in the Spaceport Engineering and Technology Directorate at Kennedy Space Center. The branch's operations and research areas include life sciences Space Shuttle payloads, bioregenerative life-support for long-duration spaceflight and environmental/ecological stewardship KSC-00pp0697

The Space Shuttle program was the United States government's manned launch vehicle program from 1981 to 2011, administered by NASA and officially beginning in 1972. The Space Shuttle system—composed of an orbiter launched with two reusable solid rocket boosters and a disposable external fuel tank— carried up to eight astronauts and up to 50,000 lb (23,000 kg) of payload into low Earth orbit (LEO). When its mission was complete, the orbiter would re-enter the Earth's atmosphere and lands as a glider. Although the concept had been explored since the late 1960s, the program formally commenced in 1972 and was the focus of NASA's manned operations after the final Apollo and Skylab flights in the mid-1970s. It started with the launch of the first shuttle Columbia on April 12, 1981, on STS-1. and finished with its last mission, STS-135 flown by Atlantis, in July 2011.