Active site gorge of hAChE phosphonylated by aged soman.
Active site gorge of hAChE phosphonylated by aged soman. The figure was made from a model of aged hAChE–soman conjugate. The ligands are represented as balls and sticks and key active site residues are represen... More
MERS Coronavirus - A close up of a ball of food and a picture of a cel...
A schematic showing the fluorescent signal obtained from the RNA of the MERS coronavirus using DTRA-developed technology that combines point-ofsampling amplification of the RNA and a signaling beacon made out o... More
A scientist from the Edgewood Chemical Biological Center
A scientist from the Edgewood Chemical Biological Center (ECBC) separates metal-organic framework (MOF) material from an aluminum surface after electrospinning it. Electrospinning turns a liquid polymer solutio... More
Antimicrobial resistance (AMR), or the ability of a
Antimicrobial resistance (AMR), or the ability of a microbe to resist the effects of medication previously used to treat them, is a growing threat to both public health and the warfighter.
Edgewood Chemical Biological Center Acting Director
Edgewood Chemical Biological Center Acting Director Eric Moore, Ph.D., (left) and Michael Feasel, Ph.D., discuss carfentanil exposure effects and their relation to warfighters. (Official ECBC photo)
JSTO in the News - A close up of a sign with a sky background
Stock image for JSTO in the News.
(A) Schematic of the confocal laser beam trap (B) The
(A) Schematic of the confocal laser beam trap (B) The laser profile of the trapping hollow cone (C) A particle is trapped at the focal point Figure courtesy of Optics Letters.
Representation of the Burkholderia pan-genome and
Representation of the Burkholderia pan-genome and sub-components. The purple circle represents the number of unique genes found within the genus Burkholderia; the red circle represents the genes shared among B.... More
Chemical distribution profiles in stratum corneum (SC)
Chemical distribution profiles in stratum corneum (SC) after 15 and 60 min of exposure on normal skin. High concentration of chemical remained in 2 μm thickness to the skin surface within 60 minutes of exposure... More
Enzymes counter chemical threats
Enzymes counter chemical threats
Member of the Special Response Team conducting a Sensitive
Member of the Special Response Team conducting a Sensitive Site Assessment Mission wearing a CB Lightweight Integrated Thermal Ensemble (CB Lite) Suit. (Photo courtesy of U.S. Army Research, Development and Eng... More
Schematic of integrated liver, heart and lung models
Schematic of integrated liver, heart and lung models interconnected by microfluidic devices that simulate the human circulatory system. (Graphic courtesy of Dr. Anthony Atala, Wake Forest Institute for Regenera... More
The analyte (red) potentially in a complex matrix such
The analyte (red) potentially in a complex matrix such as blood and urine. The paper itself could be used to directly collect samples from the air. (Graphic courtesy of Trevor Glaros, Edgewood Chemical Biological Center)
Amy Shurtleff, Ph.D., works in a biosafety level 4
Amy Shurtleff, Ph.D., works in a biosafety level 4 laboratory at USAMRIID. Shurtleff is part of a team that evaluated the protective efficacy of Merck's EBOV vaccine, V920. (Image courtesy of USAMRIID)
Notional image illustrating how light reflected from
Notional image illustrating how light reflected from butterfly wing scales results in unique data when in the presence of different vapors. Experimental data is shown for dichloropentane (orange), a mustard gas... More
A single dose of Cyto-111 provides protection in mice
A single dose of Cyto-111 provides protection in mice at times refractory to antitoxin treatment. Mice lethally intoxicated with 2x LD50 BoNT/A become symptomatic between 6-8 hours after intoxication. Treatment... More
How Sweet It Is: GlycoSCORES Speed Drug Development
Loading TECAN: Researchers remove a sample plate from the robotic handler. With 384 sample spots (including several for calibration/calibration check), a vast number of permutations and combinations of glycosyl... More
The Climate SOM Process within SAHARA, including mapping
The Climate SOM Process within SAHARA, including mapping and training phases. The training phase includes interim steps which feedback to themselves iteratively; the iteration count is a tuning parameter. The m... More
Next-Generation DNA Delivery Devices
A number of DNA vaccine delivery devices are in commercial development which have the potential to overcome these logistical burdens. Several of them will be evaluated by medical personnel at the Delivery of Nu... More
Ebola Virus Disease, US Navy Photogrpah
When Ebola virus disease (EVD) reared its head in May in the Congo, the world was armed with the rVSV-ZEBOV vaccine thanks to interagency collaboration efforts by the Defense Threat Reduction Agency’s Chemical ... More
Porton Man is a sensor-equipped mannequin capable of
Porton Man is a sensor-equipped mannequin capable of detecting and evaluating the impact of chemical and biological agents on warfighter uniforms, gloves and other outerwear. (Photo courtesy of Terrence D’Onofrio, Ph.D.)
An Epic Tool for Force Readiness
Proposed list of EpiGrid diseases and release schedule.
Collaboration between Defense Threat Reduction Agency,
Collaboration between Defense Threat Reduction Agency, Chemical and Biological Technologies Department and Wake Forest Institute for Regenerative Medicine resulted in developing organ-on-a-chip technology. The ... More
The rapid design, assembly and validation of paper-based
The rapid design, assembly and validation of paper-based biomolecular sensors for the portable detection of Zika virus is shown here. Using sequence information from online databases, primers for isothermal RNA... More
Dr. Hann, Director of the Joint Science and Technology
Dr. Hann, Director of the Joint Science and Technology Office at the Defense Threat Reduction Agency, examines the liver module of the XCEL project at Los Alamos National Laboratory.
Michael Feasel, Ph.D., ECBC, studies the metabolic
Michael Feasel, Ph.D., ECBC, studies the metabolic effects of carfentanil. (Official ECBC photo)
Confocal microscope image of a tissue-engineered microvessel
Confocal microscope image of a tissue-engineered microvessel formed from human brain microvascular endothelial cells in a 3D matrix. Image courtesy of Prof. Peter Searson, Johns Hopkins University.
Members of the Virginia Army National Guard's 34th
Members of the Virginia Army National Guard's 34th Civil Support Team provide feedback to members of the Tactical All-Hazards Ensemble program team. (Official DTRA photo)
A U.S. Army soldier wears the DTRA-funded CBLITE uniform
A U.S. Army soldier wears the DTRA-funded CBLITE uniform during an October 2016 demonstration. Official DTRA Photo.
Global distribution of Burkholderia pseudomallei.
Global distribution of Burkholderia pseudomallei.
A researcher demonstrates how the RSDL medical
A researcher demonstrates how the RSDL medical countermeasure is applied ot the skin.
Geographical distribution of the Ebola virus disease
Geographical distribution of the Ebola virus disease outbreak in the Democratic Republic of the Congo as of June 2017. Graphic courtesy of World Health Organization.
Three protein biomarkers that fluctuate differently
Three protein biomarkers that fluctuate differently in bacterial and viral infections. (Image courtesy of PLOS ONE.)
Continuous electrical sensing during bacterial culture.
Continuous electrical sensing during bacterial culture. (Image courtesy of GE Global Research)
Empowering the Development of Genomics Expertise (EDGE)
Empowering the Development of Genomics Expertise (EDGE) offers a suite of analytical tools to assist with mission and threat analysis of biological threats for operational utility. (Graphics by DTRA)
Continuous Liquid Interface Production (CLIP) Process.
Continuous Liquid Interface Production (CLIP) Process. Microneedle patches of virtually any design are produced within two to 10 minutes. (Image courtesy of Shaomin Tian, Ph.D., and Sue Mecham, Ph.D.)
Sample to Sequence - A diagram of a computer and a printer
Sample to Sequence
Official DTRA graphics - A number of different screens on a green back...
Official DTRA graphics
Marburg virus particles (in blue) and sperm originating
Marburg virus particles (in blue) and sperm originating from the seminiferous tubule, a site of immune privilege and sperm production in the testes, of a non-human primate that survived Marburg virus infection.... More
Pioneering the Data Frontier: Digital Battlespace Management
Pioneering the Data Frontier: Digital Battlespace Management
Marines monitoring mission progress inside the
Marines monitoring mission progress inside the representative Combat Operations Center (COC). (Jason Hudson, Global Systems Engineering)
Tony Buhr, Ph.D., a biologist at NSWCDD, works at a
Tony Buhr, Ph.D., a biologist at NSWCDD, works at a biological safety cabinet on DTRA-funded work on biological warfare agents.
A new project funded by the DTRA’s Joint Science and
A new project funded by the DTRA’s Joint Science and Technology Office and conducted by a team of Lawrence Livermore National Laboratory (LLNL) scientists have created 'second skin,' a new material that is brea... More
Schematic of platelet membrane-coated nanoparticles
Schematic of platelet membrane-coated nanoparticles (PNPs) for the treatment of immune thrombocytopenia purpura (ITP). (A) To fabricate PNPs, the plasma membrane from fresh platelets is derived and then coated ... More
This chart shows VX dose lethality curves in animals
This chart shows VX dose lethality curves in animals decontaminated with either RSDL or Veriox two minutes after cutaneous exposure.
Prophylactic activity of engineered EcN against P.
Prophylactic activity of engineered EcN against P. aeruginosa infection. (a) Scheme for pre colonization of EcN in the GI tract followed by P. aeruginosa infection. (b) Colonization of EcN was assessed by fecal... More
Heatmaps representing the members of the top set of
Heatmaps representing the members of the top set of genes in I interferon (IFN) induction (left), IFN response (middle) and antioxidative response (right) signalling pathways in A549 cells 96 h.p.i. with hRSV N... More
Integrated Early Warning includes a family of chemical
Integrated Early Warning includes a family of chemical and biological defense systems. A fixed site example is depicted above. (Official DTRA image)
Schematic representation of a CNT membrane functionalized
Schematic representation of a CNT membrane functionalized with chemical-threat-responsive polymers. In a safe environment the responsive polymer chains are extended and the material allows rapid transport of wa... More
Comparison of protection levels provided by two different
Comparison of protection levels provided by two different garments. Garment (1) front and back performance map. Garment (2) front and back performance map.(Courtesy image from Dstl)
Journal of Chemical and Biological Defense
Journal of Chemical and Biological Defense
Using Sprayable Slurry, warfighters recently demonstrated
Using Sprayable Slurry, warfighters recently demonstrated CWA vehicle decontamination (using a HUMVEE with simulated contamination) during hands-on, operationally relevant training scenarios at Joint Base Lewis... More
The auto-inductive cascade for the detection of nerve
The auto-inductive cascade for the detection of nerve agent surrogate, DFP, through fluoride (signal) amplification. Figure courtesy of Chemistry - A European Journal
Using Sprayable Slurry, warfighters recently demonstrated
Using Sprayable Slurry, warfighters recently demonstrated CWA vehicle decontamination (using a HUMVEE with simulated contamination) during hands-on, operationally relevant training scenarios at Joint Base Lewis... More
An array of blue light-emitting diodes (LED) and a
An array of blue light-emitting diodes (LED) and a time-gated specialized camera are used to collect whole body image data from a test mannequin. (Image courtesy of Howard J. Walls, Ph.D., Aerosol Control Group... More
Marburg virus particles (in blue) and sperm originating
Marburg virus particles (in blue) and sperm originating from the seminiferous tubule, a site of immune privilege and sperm production in the testes, of a non-human primate that survived Marburg virus infection.... More