synthetic biology

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Portable Biomolecular Manufacturing

Portable Biomolecular Manufacturing

By combining freeze-dried, cell-free (FD-CF) reaction pellets with DNA instructions for protein synthesis, therapeutics and other molecular tools can be manufactured on-site, on-demand with the simple addition ... More

WRIGHT-PATTERSON AIR FORCE BASE, Ohio – Members of

WRIGHT-PATTERSON AIR FORCE BASE, Ohio – Members of

WRIGHT-PATTERSON AIR FORCE BASE, Ohio – Members of the Air Force, Army and Navy Research Laboratories visit the Air Force Research Laboratory’s Materials and Manufacturing Directorate to learn of the unique cap... More

Member of the Special Response Team conducting a Sensitive

Member of the Special Response Team conducting a Sensitive

Member of the Special Response Team conducting a Sensitive Site Assessment Mission wearing a CB Lightweight Integrated Thermal Ensemble (CB Lite) Suit. (Photo courtesy of U.S. Army Research, Development and Eng... More

Chemical and Biological Defense Science & Technology Conference

Chemical and Biological Defense Science & Technology Conference

The Defense Threat Reduction Agency's Chemical and Biological Technologies Department will host the 2017 Chemical and Biological Defense Science & Technology (CBD S&T) Conference Nov. 28-30, 2017, in Long Beach, Calif.

The analyte (red) potentially in a complex matrix such

The analyte (red) potentially in a complex matrix such

The analyte (red) potentially in a complex matrix such as blood and urine. The paper itself could be used to directly collect samples from the air. (Graphic courtesy of Trevor Glaros, Edgewood Chemical Biological Center)

Amy Shurtleff, Ph.D., works in a biosafety level 4

Amy Shurtleff, Ph.D., works in a biosafety level 4

Amy Shurtleff, Ph.D., works in a biosafety level 4 laboratory at USAMRIID. Shurtleff is part of a team that evaluated the protective efficacy of Merck's EBOV vaccine, V920. (Image courtesy of USAMRIID)

Notional image illustrating how light reflected from

Notional image illustrating how light reflected from

Notional image illustrating how light reflected from butterfly wing scales results in unique data when in the presence of different vapors. Experimental data is shown for dichloropentane (orange), a mustard gas... More

BOSTON, Mass. – Col. Charles Ormsby, Director, Materials

BOSTON, Mass. – Col. Charles Ormsby, Director, Materials

BOSTON, Mass. – Col. Charles Ormsby, Director, Materials and Manufacturing Directorate, Air Force Research Laboratory, takes a closer look at the bioengineering design pipeline during a visit to the Broad Insti... More

How Sweet It Is: GlycoSCORES Speed Drug Development

How Sweet It Is: GlycoSCORES Speed Drug Development

Loading TECAN: Researchers remove a sample plate from the robotic handler. With 384 sample spots (including several for calibration/calibration check), a vast number of permutations and combinations of glycosyl... More

The Climate SOM Process within SAHARA, including mapping

The Climate SOM Process within SAHARA, including mapping

The Climate SOM Process within SAHARA, including mapping and training phases. The training phase includes interim steps which feedback to themselves iteratively; the iteration count is a tuning parameter. The m... More

Next-Generation DNA Delivery Devices

Next-Generation DNA Delivery Devices

A number of DNA vaccine delivery devices are in commercial development which have the potential to overcome these logistical burdens. Several of them will be evaluated by medical personnel at the Delivery of Nu... More

Ebola Virus Disease, US Navy Photogrpah

Ebola Virus Disease, US Navy Photogrpah

When Ebola virus disease (EVD) reared its head in May in the Congo, the world was armed with the rVSV-ZEBOV vaccine thanks to interagency collaboration efforts by the Defense Threat Reduction Agency’s Chemical ... More

Porton Man is a sensor-equipped mannequin capable of

Porton Man is a sensor-equipped mannequin capable of

Porton Man is a sensor-equipped mannequin capable of detecting and evaluating the impact of chemical and biological agents on warfighter uniforms, gloves and other outerwear. (Photo courtesy of Terrence D’Onofrio, Ph.D.)

Nano-Bio Materials Consortium and AFRL release RFP for Smart MedTech innovations

Nano-Bio Materials Consortium and AFRL release RFP for Smart MedTech i...

A soft ultrasonic patch that continuously measures blood pressure waveforms is a current project at NBMC in collaboration with the Dr. Sheng Xu research group at the University of California, San Diego, Departm... More

A New DOMANE for the Pandemic Era

A New DOMANE for the Pandemic Era

Adaptive Trials test multiple treatments against the Standard of Care (SOC) simultaneously. If one treatment performs well it can become the new SOC and future treatments are evaluated against it. If a treatmen... More

WRIGHT-PATTERSON AIR FORCE BASE, Ohio – Dr. Chia Hung

WRIGHT-PATTERSON AIR FORCE BASE, Ohio – Dr. Chia Hung

WRIGHT-PATTERSON AIR FORCE BASE, Ohio – Dr. Chia Hung discusses current research in the biology lab at the Air Force Research Laboratory’s Materials and Manufacturing directorate during a visit of members of th... More

Members of the Virginia Army National Guard's 34th

Members of the Virginia Army National Guard's 34th

Members of the Virginia Army National Guard's 34th Civil Support Team provide feedback to members of the Tactical All-Hazards Ensemble program team. (Official DTRA photo)

Continuous electrical sensing during bacterial culture.

Continuous electrical sensing during bacterial culture.

Continuous electrical sensing during bacterial culture. (Image courtesy of GE Global Research)

Empowering the Development of Genomics Expertise (EDGE)

Empowering the Development of Genomics Expertise (EDGE)

Empowering the Development of Genomics Expertise (EDGE) offers a suite of analytical tools to assist with mission and threat analysis of biological threats for operational utility. (Graphics by DTRA)

BOSTON, Mass. – Amber Gilbert (left) discusses biotechnology

BOSTON, Mass. – Amber Gilbert (left) discusses biotechnology

BOSTON, Mass. – Amber Gilbert (left) discusses biotechnology with the Ginkgo Bioworks foundry team during an Air Force Research Laboratory ‘bluing’ trip, April 24. The visit to the Ginkgo foundry exposed the AF... More

Sample to Sequence - A diagram of a computer and a printer
Official DTRA graphics - A number of different screens on a green background
Marburg virus particles (in blue) and sperm originating

Marburg virus particles (in blue) and sperm originating

Marburg virus particles (in blue) and sperm originating from the seminiferous tubule, a site of immune privilege and sperm production in the testes, of a non-human primate that survived Marburg virus infection.... More

Pioneering the Data Frontier: Digital Battlespace Management

Pioneering the Data Frontier: Digital Battlespace Management

Pioneering the Data Frontier: Digital Battlespace Management

Prophylactic activity of engineered EcN against P.

Prophylactic activity of engineered EcN against P.

Prophylactic activity of engineered EcN against P. aeruginosa infection. (a) Scheme for pre colonization of EcN in the GI tract followed by P. aeruginosa infection. (b) Colonization of EcN was assessed by fecal... More

BOSTON, Mass. – Dr. Maneesh Gupta (rt.) discusses

BOSTON, Mass. – Dr. Maneesh Gupta (rt.) discusses

BOSTON, Mass. – Dr. Maneesh Gupta (rt.) discusses biotechnology with a member of the Ginkgo Bioworks foundry team during an Air Force Research Laboratory ‘bluing’ trip, April 24. The visit to the Ginkgo foundry... More

Schematic representation of a CNT membrane functionalized

Schematic representation of a CNT membrane functionalized

Schematic representation of a CNT membrane functionalized with chemical-threat-responsive polymers. In a safe environment the responsive polymer chains are extended and the material allows rapid transport of wa... More

Comparison of protection levels provided by two different

Comparison of protection levels provided by two different

Comparison of protection levels provided by two different garments. Garment (1) front and back performance map. Garment (2) front and back performance map.(Courtesy image from Dstl)

Journal of Chemical and Biological Defense

Journal of Chemical and Biological Defense

Journal of Chemical and Biological Defense

An array of blue light-emitting diodes (LED) and a

An array of blue light-emitting diodes (LED) and a

An array of blue light-emitting diodes (LED) and a time-gated specialized camera are used to collect whole body image data from a test mannequin. (Image courtesy of Howard J. Walls, Ph.D., Aerosol Control Group... More

Marburg virus particles (in blue) and sperm originating

Marburg virus particles (in blue) and sperm originating

Marburg virus particles (in blue) and sperm originating from the seminiferous tubule, a site of immune privilege and sperm production in the testes, of a non-human primate that survived Marburg virus infection.... More

D5SICS-skeletal

D5SICS-skeletal

Haworth projection of dNaM.

D Na M Skeletal

D Na M Skeletal

Haworth projection of dNaM.

Linking-Human-Diseases-to-Animal-Models-Using-Ontology-Based-Phenotype-Annotation-pbio.1000247.g006

Linking-Human-Diseases-to-Animal-Models-Using-Ontology-Based-Phenotype...

Based on the diagram from KEGG [31], the double gray line represents the plasma membrane, and the dashed line the nuclear membrane. All known shha pathway members are shown; those with recorded mutant EQ annot... More

Linking-Human-Diseases-to-Animal-Models-Using-Ontology-Based-Phenotype-Annotation-pbio.1000247.g005

Linking-Human-Diseases-to-Animal-Models-Using-Ontology-Based-Phenotype...

Each of the four panels shows one of the four similarity measurements, comparing the score for alleles of the same gene (intra, in black) versus alleles of all other genes (inter, in gray), for each of the 11 ... More